Jan 2023: We are thrilled to join the Department of Computational Medicine and Bioinformatics at University of Michigan and start a new journey of more exciting researches!
We are also recruting talented students and postdoctoral scholars to join our team. For more information, please refer to our homepage and feel free to contact us!
The Au Lab is seeking candidates for two postdoctoral research scholar positions to work on
Postdoctoral Research Scholar in bioinformatics method development:
We are looking for a postdoctoral scholar to develop statistical and computational/algorithmic methods
for high-throughput sequencing data analyses, such as transcriptome and epigenetics using PacBio and
Oxford Nanopore Technologies. Background on mathematics, statistics, computer science or degree in a
related field is desirable.
Postdoctoral Research Scholar in computational biology
We are looking for a postdoctoral scholar in biology background. Our lab performs world leading science
in development process and cancer research. Our team focuses on making meaningful advances to understand
development process and cancer, using cutting edge technologies (third generation sequencing technology)
to create authentic models and gain novel biological insight in transcriptome and epigenetics level. A
typical candidate would have skills in including but not limited to implementing basic in-house
bioinformatics tools, collaborating with statistician and computational biologists to elucidate
biological discovery and mining out biological insights. Background on biology, computational biology or
bioinformatics is desirable.
Strong ability in statistical analysis or computer programming (python/perl, C/C++, R, Matlab) is
The postdoctoral research scholars will have the opportunity to collaborate with internationally
recognized biomedical scientists at University of Iowa Carver College of Medicine, Stanford University,
University of Oxford and Pacific Biosciences.
Lab Arts: Genome Research Cover Drafts
Single-molecule long-read sequencing reveals the chromatin basis of gene expression. Genome
Research. 2019 08; 29(8)1329-1342
Thoughts behind Arts
Cats and Yarns:
The DNA strands are wrapped around histone protein cores like "yarn balls", which form
nucleosomes. Some DNA regions (threads) are folded as “close chromatin” while loose threads
are “open chromatin”. The previous techniques can only identify these epigenetics statuses
at bulk level while our new method “MeSMLR-seq” makes the first sharp-eyed observation as
cat: nucleosome positioning and chromatin openness at each single DNA molecules (threads and
balls with different colors) can be seen. In addition, cat likes yarn balls.
Railway, Mountains, and Valleys:
Railway represents the double-stranded DNA molecules. Different railways stretching around
mountains (i.e., nucleosomes) indicate different DNA molecules. The road lights represent
the exogenous 5mC at GpC sites introduced by our MeSMLR-seq protocol, which label and show
the linker DNA fragments between nucleosomes (mountains) and the open chromatin regions
(town). The town with many road lights shows vigorous of human activities. i.e., the open
chromatin regions are active for many biological processes. For example, the
buildings/houses indicate transcription factors binding to open promotors for gene
transcriptions. The dark mountain areas represent the regions occupied by nucleosomes, with
less biological events.
Temples, Moutains and Clouds:
This is similar with “railway and mountain”, where cloud represents DNA molecules and pine
tree represents the exogenous 5mC at GpC sites introduced by MeSMLR-seq. It could be in a
style of Chinese painting.